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Fallout 4

End of the Line

Nathan Garvin

Like most Institute quests, this one begins by talking to Father. Go talk to him and he’ll ask how the meeting went. Answer however you wish. Now, if you have contacted the Railroad you will get some text here calling your allegiance into question a bit, and you can even outright tell Father they are your allies but no matter what you do your goal (from Father, who is outright commanding you at this point) is to “Kill Desdemona”.

Railroad HQ

Make your way to the Railroad and kill everybody you find dwelling down here. Be sure to bring healing items and a companion other than "Deacon" iconDeacon for this fight. There is no need to actually talk to Desdemona, but you can tell her you are here to kill her nonetheless. It would be better though to get hidden and get in sneak attacks to thin the herd. After you kill Desdemona, you will be told to “Eliminate Railroad Leaders”, which include Tinker Tom, Glory, Doctor Carrigan and Deacon. Note that if you have Deacon as a companion out waiting for you at a Settlement, you will have to go there and kill him separately as well. There is really no notable loot to be had, but Desdemona does have the “"Railroad HQ" iconRailroad HQ Key” and a Railway Rifle you should grab. Warp back to "The Institute" iconThe Institute once you are done.

Talk to Father to report your success and he will sympathize a bit and tell you that the Brotherhood is next. Because OF COURSE they are. Well, at least you are already enemies with them. He will go over how the Brotherhood is quite a bit bigger than just the Railroad was, with other factions out in the Wastes. As he talks, this quest will officially end and the next quest named "Airship Down" iconAirship Down will begin. Father will ask you to go see Doctor Watson to go over his plan on how to deal with the Brotherhood, but we’ll cover that under “Airship Down” .

Objective Reward
For exterminating the Railroad leadership 590 XP
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Guide Information
  • Publisher
    Bethesda Softworks
  • Platforms,
    PC, PS4, XB One
  • Genre
  • Guide Release
    16 December 2015
  • Last Updated
    11 May 2024
    Version History
  • Guide Author
    Nathan Garvin, Greg Wright

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It’s just another day. Having just been accepted into Vault 111, you spend the morning with your family going about your daily routine. That is until alarms blare out, signalling a nuclear attack. You and your family sprint towards the Vault along with everyone else in the neighborhood just as a bomb explodes nearby. After surviving the blast, you are lowered into the Vault and enter cryosleep. Two hundred years pass and you awake to a world ravaged by nuclear war. You are the Sole Survivor and what awaits you is a mystery as you set out to conquer the Wasteland.

Our guide will be a complete companion while you journey through the wilds of Fallout 4. You can find a plethora of information including the following:

  • A start to finish walkthrough with every area in between covered.
  • Combat details, SPECIAL explanation and general gameplay information.
  • VATS And You!: Getting to know your PIPBOY.
  • All faction quests explained including the consequences of favoring one over the others.
  • Information on Settlements and items for construction.
  • Bobblehead locations, collectibles and full Trophy/Achievement guide.
  • Settlement Guide complete with how to set up and manage settlements, what perks are beneficial etc.
  • Companion chapter detailing each companion character, where to acquire them and the pros/cons of each.
  • A detailed Character Creation guide fully examining the best builds and what each perk does.
  • Automatron and Wasteland Workshop DLC information provided, including a full walkthrough for Automatron.
  • A complete walkthrough of the “Far Harbor” DLC complete with information on every side quest.

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