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How to Cure the Disease Debuff – Nightingale

Scott Peers

There are several different status effects that can afflict you in Nightingale, ranging from the relatively harmless impact of rain (and the Wet debuff that it instils) to the more harmful effects of hail, which can actually kill you if you don’t protect yourself from it in time. Each biome will have its own major threats, and the Disease status effect is one that you’ll encounter most often in Swamp biomes. It functions in much the same way as hail, in that it will slowly kill you if you don’t do something about it. On this page, we’ll briefly tell you everything you need to know about how to remove the Disease status effect in Nightingale.

The marshlands of the Swamp biome can be a beautiful yet treacherous place to explore.

How to Avoid the Disease Debuff

The first thing you should know about disease in Nightingale is how to avoid it in the first place. As mentioned above, the main risk is in the Swamp biomes, but you’re not always vulnerable to getting it wherever you roam. You should only be exposed to disease if you actually enter the marshy water within a Swamp biome, so it’s easy enough to avoid if you pay attention to your surroundings. With that said, there’s a good chance that you’ll have to run through some marshland to reach a specific POI, chest, or group of enemies, so you may not always be able to avoid it entirely.

If you do happen to find yourself in the swamp marshlands, you’ll find that acquiring disease occurs in much the same way as the Wet debuff, whereby the longer you stay in the water, the more the bar in the center of the screen will fill. Once the bar is full, you’ll acquire the debuff. However, unlike the relatively harmless Wet debuff, which will go away on its own without inflicting any damage, the Disease debuff will slowly eat away at your health, so you want to avoid getting it at all costs.

(1 of 2) You may need to venture into the swamp to kill specific enemies or find loot.

You may need to venture into the swamp to kill specific enemies or find loot. (left), You can see the disease debuff on your entire body, including on your hands and weapon in first-person. (right)

How to Cure the Disease Debuff

So, it’s likely that you’ll get the Disease debuff sooner or later in Nightingale, but how can you cure it? Unfortunately, there isn’t a specific potion or curative to remove it in the early game, and we haven’t been able to find one at all during the early access, but you can counter the debuff by outlasting it. The best (and cheapest) way to do this is with Healing Salves, which you can craft by combining any piece of Bone and any piece of Fiber at the Cooking Station. It only costs one of each material per salve, so you can easily craft a stack of them ready for your adventures.

If you want to learn more about how to craft healing salves and potions, be sure to check our How to Craft Healing Salves and Potions page.

The key thing to note here is that you should use a Healing Salve as soon as you acquire the Disease debuff. It will inflict enough damage to continually chip away at your health, but the Healing Salve will be enough to counter it for as long as the debuff lasts. In general, you should only need to outlast the debuff for 20 – 30 seconds, but you may end up using more than one healing salve depending on how much maximum health you have.

Ultimately, in an ideal scenario, you can avoid getting the disease debuff in the first place by moving in and out of swamp marshlands to deplete the progress bar. Resetting it in this way should give you enough time to jump between islands of raised land above the water, but we know that this won’t always be possible. Just be sure to have plenty of healing salves at hand whenever you need to go through a swamp, and you should be fine.

If you want to learn more about different status effects in Nightingale including some which are applied by different types of weather, see the links below.

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Guide Information
  • Publisher
    Inflexion Games
  • Platforms,
  • Genre
    Adventure, RPG, Survival
  • Guide Release
    12 February 2024
  • Last Updated
    12 March 2024
  • Guide Author

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Nightingale is a PvE open-world survival crafting game with a few unique features for the genre. First among these is the Realm Card system, whereby players can discover and craft Major or Minor realm cards to influence aspects of procedurally generated worlds or character attributes respectively. You may find yourself in a more forgiving or hostile world depending on the Major cards you use, but the Minor cards can give you an edge against foes with boosts to damage, health, stamina, or other aspects of survival. The game is set in the Victorian era and has more than a little influence from Steampunk fiction, so if that’s anything like your thing, you’ll love this world!

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