There are 300 optional missions in Crisis Core Final Fantasy VII: Reunion. Monsters in Midgar (M2-1) can be found in the Monster Research Project Category.

How to Unlock the Monsters in Midgar Missions in Crisis Core Reunion¶

The Monsters in Midgar set of missions are special, as they are all missable and unlocked individually, instead of as a whole set. As you go through the earlier chapters of the main story, you will need to speak with specific NPCs in Midgar, who will unlock the various missions in this sub-category. The reason they are missable is because once you progress enough in Chapter 7, you will lose access to Midgar completely, so you won’t be able to return there unless you have an earlier save or play on New Game+.

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(1 of 6) The NPC that unlocks Mission 2-1-1

Mission	Unlock	Enemies	Reward
2-1-1: Beginnings	Chapter 3; Speak to man upstairs in Sector 8 - Fountain	Grashtrike, Fly Eye	Poison Materia
2-1-2: Approaching the Outskirts	Chapter 3; Speak to employee walking around in Sector 8 - LOVELESS Avenue	Grashtrike, Fly Eye	Fire Armlet
2-1-3: Sightings in Sector 5	Chapter 4; Speak to girl in Sector 5 Slums - Market after retrieving wallet	Grashtrike, Raijincho, Fly Eye	Phoenix Down
2-1-4: Defend the Slums	Chapter 4; Speak to girl in Sector 5 Slums - Street	Grashtrike, Raijincho, Fly Eye	Fire Ring
2-1-5: Highway Closed	Chapter 5; Speak to Trooper in Shinra Building Entrance, upstairs	Fly Eye, Raijincho, Trap	SPR Up Materia
2-1-6: Truth in the Wasteland	Chapter 5; Complete all previous missions, then go to Shinra HQ Exhibit Room and speak to Researcher	Fly Eye, Raijincho, Trap	Ice Ring

Unlocking the missions is probably more trouble than actually completing them, as the missions are pretty simple and don’t have a lot to worry about in them. In fact, you will be spending the whole time going through them and fighting the same enemies, especially for the first four. Once you reach the last two missions, you’ll have the addition of the Trap enemy, which is part of the Bomb family. These enemies, if you don’t defeat them quickly enough, will grow in size and eventually explode. You can easily trigger the explosion by hitting them with a fire spell.

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Don’t forget to return to the Researcher to get the !Mythril Tools key item

By the time you unlock these missions, too, you really won’t find much of worthwhile treasures from the chests. Unless you want to open all the chests to have a true 100% save file, it’s best to just ignore them and head straight for the enemy on the map. Once you complete all of the missions in the entire group, return to the Researcher you spoke to unlock 2-1-6: Truth in the Wasteland to get the Mythril Tools key item. This item is one of many needed to unlock the Midgar Full of Flowers trophy/achievement.