Chaos Fang – From the Shaman in Tri-Stone (Need Darksiders: Wrath at War save to be detected).
Pauldron of the Horseman – From the Shaman in Tri-Stone (Need Darksiders: Wrath at War save to be detected).
Dark Avenger - Kill Gharn at the end of the Cauldron.
Masher of Karkinos – Kill Karkinos at the end of The Drenchfort.
Gorewood Maul – Kill Gorewood in The Weeping Crag (Side-Quest “Find and Kill Gorewood”).
Bhethir’s Talons – Kill Bheithir in The Nook (side-Quest - “Find and Kill Bheheir”).
Omega Blade – Behind a yellow crystal in The Shattered Forge. Check out the walkthrough to the side quest “The Hammer’s Forge” for a better idea of where to find it.
Grim Talisman - From the Shaman in Tri-Stone – Complete “Shaman’s Craft” side-quest.
Guillotine - Receive from Blackroot as a reward for completing the “Sticks and stones” side-quest.
Blade Master Talisman – The Forge Lands Death Tomb -after giving Vulgrim 10 Book of the Dead pages you can open the door next to The Lost Temple to find this.
The Kingdom of the Dead
Achidna’s Fangs – The Psychameron - Kill Achidna at the end of the Psychameron.
Lich Spines - City of the Dead - Just when you use the lantern beam to raise the walkway. In the door to your right there is a wall you can run up to catch a ledge, wall run on to a beam, then another and there is the chest.
Scepter of the Deposed King – The Lair of the Deposed King - Kill the deposed King in the Lair of the Deposed King (side-Quest “Find and Kill The Deposed King”).
Demonheart Talisman – The Kingdom of the Dead Death Tomb - after giving Vulgrim 20 Book of the Dead pages you can open the door at the bottom of the spiral staircase in The Lair of the Deposed King to find this.
Keen Talisman - Boneriven - Found in one of the side rooms deep within Boneriven, a secret optional dungeon accessed through Sentinel’s Gaze.
Black Demise - Follow the secret directions on level 5 of the Soul Arbiter’s Maze to find these bad boys. Check the guide here for more info.
The Crown of the Dead - Soul Arbiter’s Maze - Defeat the Soul Arbiter on the lowest level of the Soul Arbiter’s Maze. for a full guide to getting through the maze and beating the boss check out the side quest guide for “The Chancellor’s Qurry”.
Executioner’s Hooks - Soul Arbiter’s Maze - Defeat the Soul Arbiter on the lowest level of the Soul Arbiter’s Maze. for a full guide to getting through the maze and beating the boss check out the side quest guide for “The Chancellor’s Quarry” here
Fists of Elhazar - Earth - In the last building of the dungeon, you will find these hidden away in an alcove.
Sunder – Earth - Complete the side-quest “Light of the Fallen” it is completely covered in the main walkthrough here.
Goldbringer – The Ivory Citadel - near the start of the dungeon.
Hoardseeker Talisman – The Lostlight Death Tomb - after giving Vulgrim 30 Book of the Dead pages you can open the door on the left of the main path leading from the Tree of Life to the Crystal Spire to find this.
Demonflame Renders - The Black Throne - Near the start of The Black Throne.
Mace of the Everflame - Defeat Sammael at the end of The Black Stone.
Spear of Storms - The Shadow’s Edge Death Tomb - after giving Vulgrim 40 Book of the Dead pages you can open the door near Osteogoth in Shadow’s Edge on the main path leading from the Tree of Death.
Abyssal Plate - The Shadow’s Edge Death Tomb - Destroy all of the pots around the room to have a chest spawn to the north of the area containing this.
GnoMAd Scythes - Serpent Tome - Reward for completing the side-quest “GnoMAD’s Gnomes” for a guide look here.
Abyssal Gauntlets - After selling all of the relics to Osteogoth, he will give you this item.
Heartsone Talisman - Crucible - Complete the first 25 waves in the Crucible.
Abyssal Boots - Crucible - Complete the first 50 waves in the Crucible.
Barbed Defilers - Crucible - complete the first 75 waves of the crucible.
Assassin Talisman - Crucible - Complete all 100 waves of the Crucible.
Aftermath - Crucible - Complete 100 waves of the Crucible in a single attempt.
Elemental Talisman - Crucible - Defeat Wicked K. In order to meet him, you must defeat all 100 waves of the crusible in a single sitting without dying.
Absolution - Defeat the final boss and you will earn this weapon. You will recieve it at a Serpent tome when starting a New Game +.
Lifebane - Defeat the Ice Giant in the prologue on New Game + to unlock this one.