This mission is identical, mission tasks and objectives, to the original version of Code Talker. The Extreme set of rules is pretty self-explanatory, as it basically means that enemies will deal more damage to you, meaning that direct combat is not something you want to do. You have full use of your tools and Buddies in these missions, except for the Chicken Hat and Reflex Mode.

The toughest portion of this mission is definitely the beginning with the Skull snipers, as one hit from them under normal circumstances will mean instant death. However, if you play as a character with Tough Guy and the strongest Battle Armor, then you should be able to withstand a shot from them. If you have Quiet, use her to deal with the snipers or you could try to run past them all to get to the mansion, which makes the second part much easier.